2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

Base Information

Chemical Name:2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine
CAS No.:383882-58-4
Molecular Formula:C₁₉H₂₀N₂O₆
Molecular Weight:372.378
Hs Code.:

Synonyms:2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

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Chemical Property of 2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

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Technology Process of 2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

There total 10 articles about 2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 289681-50-1
((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

: 383882-58-4
2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 ℃; for 0.166667h;
DOI:10.1006/bioo.2001.1209

Reference yield:

: 1603-40-3
3-methylpyridin-2-ylamine

: 383882-58-4
2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 73 percent / HIO₄*2H₂O; I₂ / acetic acid; H₂O; H₂SO₄ / 4 h / 80 °C

2.1: NaNO₂; conc. H₂SO₄ / 0.25 h / 60 °C

2.2: 75 percent / H₃BO₃ / H₂O / 0 - 100 °C

3.1: 71 percent / P(C₆H₅)3; diethyl azodicarboxylate / dioxane / 1.5 h / 20 °C

4.1: 73 percent / bis(dibenzylideneacetone) palladium⁽⁰⁾; 1,3-bis(diphenylphosphino)propane; tri-n-butylamine / acetonitrile / 8 h / 80 °C

5.1: 80 percent / CH₃COOH; tetra-n-butylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

With tributyl-amine; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; iodine; acetic acid; periodic acid; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; sulfuric acid; water; acetic acid; acetonitrile;
DOI:10.1006/bioo.2001.1209

Reference yield:

: 83467-48-5
1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 383882-58-4
2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: (NH₄)2SO₄; 1,1,1,3,3,3-hexamethyldisilazane / 2 h / Heating

1.2: 70 percent / K₂CO₃ / methanol / 0.5 h / 0 - 5 °C

2.1: 73 percent / bis(dibenzylideneacetone) palladium⁽⁰⁾; 1,3-bis(diphenylphosphino)propane; tri-n-butylamine / acetonitrile / 8 h / 80 °C

3.1: 80 percent / CH₃COOH; tetra-n-butylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

With ammonium sulfate; tributyl-amine; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; acetonitrile;
DOI:10.1006/bioo.2001.1209