((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

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Chemical Name:((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol
CAS No.:289681-50-1
Molecular Formula:C₃₅H₃₈N₂O₆Si
Molecular Weight:610.782
Hs Code.:

Synonyms:((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

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Chemical Property of ((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

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Technology Process of ((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

There total 8 articles about ((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 130277-32-6
((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol

: 289681-48-7
5-iodo-3-methyl-2-[2-(4-nitrophenyl)ethoxy]pyridine

: 289681-50-1
((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

Guidance literature:: With tributyl-amine; 1,3-bis-(diphenylphosphino)propane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 80 ℃; for 8h;
DOI:10.1006/bioo.2001.1209

Reference yield:

: 1603-40-3
3-methylpyridin-2-ylamine

: 289681-50-1
((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 73 percent / HIO₄*2H₂O; I₂ / acetic acid; H₂O; H₂SO₄ / 4 h / 80 °C

2.1: NaNO₂; conc. H₂SO₄ / 0.25 h / 60 °C

2.2: 75 percent / H₃BO₃ / H₂O / 0 - 100 °C

3.1: 71 percent / P(C₆H₅)3; diethyl azodicarboxylate / dioxane / 1.5 h / 20 °C

4.1: 73 percent / bis(dibenzylideneacetone) palladium⁽⁰⁾; 1,3-bis(diphenylphosphino)propane; tri-n-butylamine / acetonitrile / 8 h / 80 °C

With tributyl-amine; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; iodine; periodic acid; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium nitrite; diethylazodicarboxylate; In 1,4-dioxane; sulfuric acid; water; acetic acid; acetonitrile;
DOI:10.1006/bioo.2001.1209

Reference yield:

: 83467-48-5
1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 289681-50-1
((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: (NH₄)2SO₄; 1,1,1,3,3,3-hexamethyldisilazane / 2 h / Heating

1.2: 70 percent / K₂CO₃ / methanol / 0.5 h / 0 - 5 °C

2.1: 73 percent / bis(dibenzylideneacetone) palladium⁽⁰⁾; 1,3-bis(diphenylphosphino)propane; tri-n-butylamine / acetonitrile / 8 h / 80 °C

With ammonium sulfate; tributyl-amine; 1,3-bis-(diphenylphosphino)propane; 1,1,1,3,3,3-hexamethyl-disilazane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile;
DOI:10.1006/bioo.2001.1209