(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

Base Information

Chemical Name:(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate
CAS No.:1380605-59-3
Molecular Formula:C₃₀H₃₇F₂NO₃
Molecular Weight:497.625
Hs Code.:

Synonyms:(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

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Chemical Property of (+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

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Technology Process of (+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

There total 14 articles about (+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

: 1380605-58-2
(+/-)-tert-butyl 1-[3-({cyclopentyl[4-(2,2-difluorovinyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

: 1380605-59-3
(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; under 760.051 Torr;

Reference yield:

: 1380605-56-0
(+/-)-tert-butyl 1-(3-{[cyclopentyl(4-formylphenyl)acetyl]amino}benzyl)cyclopropanecarboxylate

: 1380605-59-3
(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / 0.5 h / 60 - 110 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 760.05 Torr

With hydrogen; triphenylphosphine; palladium 10% on activated carbon; In ethanol;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1380605-59-3
(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(2,2-difluoroethyl)phenyl]acetyl}amino)benzyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 110 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 0 - 20 °C

5.1: ammonia / methanol / 4 h / 30 - 40 °C

6.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C

7.1: triphenylphosphine / 0.5 h / 60 - 110 °C

8.1: hydrogen / palladium 10% on activated carbon / ethanol / 760.05 Torr

With n-butyllithium; ammonia; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;