87661-20-9 Usage
Uses
Used in Organic Synthesis:
Tert-butyl cyclopropanecarboxylate is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, tert-butyl cyclopropanecarboxylate is utilized as an intermediate. It plays a crucial role in the synthesis of various medicinal compounds, aiding in the development of new drugs and improving the efficacy of existing ones.
Used in Agrochemical Production:
Similarly, in agrochemical manufacturing, tert-butyl cyclopropanecarboxylate serves as an intermediate. It is involved in the production of various agrochemicals, including pesticides and herbicides, enhancing crop protection and yield.
Used in Flavoring Agents for Food and Beverage Industry:
Tert-butyl cyclopropanecarboxylate is employed as a flavoring agent in the food and beverage industry, imparting a fruity aroma and taste to a variety of products, thereby enhancing their sensory appeal.
Used in Safety and Handling Protocols:
Given its highly flammable nature and potential toxicity, tert-butyl cyclopropanecarboxylate is used in the development of safety and handling protocols to ensure the protection of workers and the environment from its hazardous effects. This includes guidelines for proper storage, use, and disposal to minimize risks associated with its flammability and toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 87661-20-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,6,6 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 87661-20:
(7*8)+(6*7)+(5*6)+(4*6)+(3*1)+(2*2)+(1*0)=159
159 % 10 = 9
So 87661-20-9 is a valid CAS Registry Number.
87661-20-9Relevant academic research and scientific papers
New reactions of γ-halocarbanions: Underestimated reactive intermediates in organic synthesis
Barbasiewicz,Judka,Makosza
, p. 1846 - 1858 (2007/10/03)
Short-lived γ-halocarbanions can be trapped by active electrophiles such as aldehydes, imines, and Michael acceptors to give anionic adducts, which undergo intramolecular substitution to give substituted tetrahydrofurans, pyrrolidines, and cyclopentanes. This has underlain a new method for the synthesis of these valuable ring systems. We have determined the acidity of the γ-halocarbanion precursors and have shown that the halogen atoms in the γ-position relative to the carbanion center exert a significant stabilizing effect on the carbanion.
New reactions of γ-halocarbanions: Simple synthesis of substituted tetrahydrofurans
Makosza, Mieczyslaw,Judka, Marek
, p. 4234 - 4240 (2007/10/03)
The treatment of 4-chlorobutyronitrile, 3-chloropropyl phenyl sulfone, and other related compounds with a base afforded γ-halocarbanions that undergo fast intramolecular substitution of the halogen to produce substituted cyclopropanes. We found that these short-lived carbanionic intermediates can be trapped with active external electrophilic partners, such as aldehydes, to give the aldol anions. These anions then undergo rapid intramolecular substitution of chloride to produce 2,3- disubstituted tetrahydrofurans. Under the right conditions, yields of tetrahydrofurans are excellent. Similar reactions with ketones gives 2,2,3-trisubstituted furans, but this process is usually less efficient. Ratios between the rates of intramolecular and intermolecular processes were qualitatively estimated by competitive experiments. It was shown that y-halo and y-trimethylammonium substituents substantially increase the kinetic CH acidity of alkane nitriles and sulfones.
