(2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

Base Information

Chemical Name:(2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate
CAS No.:1419013-80-1
Molecular Formula:C₁₃H₁₄Cl₃NO₄
Molecular Weight:354.617
Hs Code.:

Synonyms:(2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

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Chemical Property of (2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

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Technology Process of (2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

There total 3 articles about (2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₂Cl₃NO₄

: 1419013-80-1
(2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

: ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

Guidance literature:: With sodium tetrahydroborate; In dichloromethane; at -78 ℃; for 3h; Overall yield = 7 mg; diastereoselective reaction;
DOI:10.1021/ol303011f

Reference yield:

: 1118754-99-6
(S)-ethyl 2-diazo-3-hydroxy-3-phenylpropanoate

: 1419013-80-1
(2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

: ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / hexane / 18 h / 20 °C

2: Oxone; sodium hydrogencarbonate / dichloromethane; acetone; water / 0.67 h / 0 - 20 °C

3: sodium tetrahydroborate / dichloromethane / 3 h / -78 °C

With Oxone; sodium tetrahydroborate; sodium hydride; sodium hydrogencarbonate; In hexane; dichloromethane; water; acetone;
DOI:10.1021/ol303011f

Reference yield:

: ethyl 2-diazo-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

: 1419013-80-1
(2S,3S)-ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

: ethyl 2-hydroxy-3-phenyl-3-(2,2,2-trichloroacetamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone; sodium hydrogencarbonate / dichloromethane; acetone; water / 0.67 h / 0 - 20 °C

2: sodium tetrahydroborate / dichloromethane / 3 h / -78 °C

With Oxone; sodium tetrahydroborate; sodium hydrogencarbonate; In dichloromethane; water; acetone;
DOI:10.1021/ol303011f