1118754-99-6

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 

Downstream Products

• 1118755-09-1 (S)-ethyl 3-(tert-butyldimethylsilyloxy)-2-diazo-3-phenylpropanoate 
• 108741-11-3 (2S,3S)-ethyl 2,3-dihydroxy-3-phenylpropanoate 
• 1354789-86-8 (4S,5S)-ethyl 4-((S)-1-acetoxyallyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 1354789-90-4 C₂₄H₂₅BrO₆ 
• 1354789-94-8 (S)-ethyl 2-hydroxy-2-((S)-hydroxy(phenyl)methyl)butanoate 
• 1354789-79-9 (S)-ethyl 2-hydroxy-2-((S)-hydroxy(phenyl)methyl)pent-4-enoate 
• 1354789-81-3 (S)-ethyl 2-hydroxy-2-((S)-hydroxy(phenyl)methyl)-3-methylpent-4-enoate 
• 1354789-83-5 (S)-ethyl 2-hydroxy-2-((S)-hydroxy(phenyl)methyl)-3,3-dimethylpent-4-enoate 
• 1354789-85-7 (2R,3S)-ethyl 3-acetoxy-2-hydroxy-2-((S)-hydroxy(phenyl)methyl)pent-4-enoate 
• 1354789-87-9 (4S,5S)-ethyl 4-((S)-1-hydroxyallyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 1354789-88-0 (4S,5S)-ethyl 4-((S)-1-((S)-2-methoxy-2-phenylacetoxy)allyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 1354789-89-1 (4S,5S)-ethyl 4-((S)-1-((R)-2-methoxy-2-phenylacetoxy)allyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 1354789-91-5 (S)-ethyl 2-hydroxy-2-((S)-hydroxy(phenyl)methyl)pent-4-ynoate 
• 1354789-93-7 (2S,3S)-ethyl 2,3-dihydroxy-2-methyl-3-phenylpropanoate 

Relevant academic research and scientific papers

Unusual reaction of β-hydroxy α-diazo carbonyl compounds with Cl3CCN/NaH and Rh(II)-catalyzed reaction of β -trichloroacetylamino α-diazo carbonyl compounds

(Matrix presented) The hydroxyl group was directly converted into the trichloroacetylamino group by reacting β-hydroxy α-diazo carbonyl compounds with Cl3CCN and NaH. Rh(II)-catalyzed reactions of the β-amino α-diazo carbonyl compounds were dis

Stereoselective bioreduction of α-diazo-β-keto esters

Diazo compounds are versatile reagents in chemical synthesis and biology due to the tunable reactivity of the diazo functionality and its compatibility with living systems. Much effort has been made in recent years to explore their accessibility and synth

Development of the enantioselective addition of ethyl diazoacetate to aldehydes: Asymmetric synthesis of 1,2-diols

A novel synthetic strategy toward the asymmetric synthesis of vicinal diols bearing a tertiary center is presented. The method encompasses the dinuclear Mg-catalyzed asymmetric addition of ethyl diazoacetate into several aldehydes, oxidation of the diazo functionality, and diastereoselective alkyl transfer of various organometallics into the resulting chiral β-hydroxy-α- ketoesters to afford a diverse range of 1,2-diols in high yield, diastereoselectivity, and chirality transfer.

Highly enantioselective synthesis of α-diazo-β-hydroxy esters using a bifunctional titanium complex

A bifunctional titanium catalyst system has been developed for the asymmetric direct-type aldol reaction of ethyl diazoacetate with aldehydes, which produced the desired products in good yields (up to 83%) with excellent enantioselectivities (up to 94% ee

The first catalytic enantioselective aldol-type reaction of ethyl diazoacetate to ketones

The aldol-type addition to ketones still represents a great challenge in asymmetric catalysis. Recently, the direct aldol reaction between the commercially available ethyl diazoacetate and aldehydes has attracted increasing attention. Ethyl diazoacetate i

Direct catalytic asymmetric aldol-type reaction of aldehydes with ethyl diazoacetate

(Matrix presented) The direct aldol-type condensation of aldehydes with ethyl diazoacetate catalyzed by the chiral complex of BINOL derivatives-Zr(OtBu)4 gave β-hydroxy α-diazo carbonyl compounds with moderate enantioselectivities (5