N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide

Base Information

• Chemical Name: N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide
• CAS No.: 380222-42-4
• Molecular Formula: C₁₄H₁₇N₅O
• Molecular Weight: 271.322
• Mol file: 380222-42-4.mol

Synonyms:N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide

Chemical Property of N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide

There total 1 articles about N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-1-(pyridin-2-yl)piperidine (144465-94-1) + 1,1'-carbonyldiimidazole (530-62-1) → 1H-imidazole (288-32-4) + N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide (380222-42-4) + C11H13N3O

Guidance literature:

In dichloromethane; at 20 ℃; for 0.75h;

Reference yield:

N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide (380222-42-4) + trifluoroacetic acid (76-05-1) → cyclobutanecarboxylic acid [(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-{(R)-3-[3-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-ureido]-pyrrolidin-1-yl}-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-amide trifluoroacetate

Guidance literature:

cyclobutanecarboxylic acid {(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-amide; N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide; With triethylamine; In dichloromethane; isopropyl alcohol; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile; Reverse phase chromatography;

Reference yield:

cyclobutanecarboxylic acid {(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-amide dihydrochloride + N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide (380222-42-4) → cyclobutanecarboxylic acid [(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-{(R)-3-[3-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-ureido]-pyrrolidin-1-yl}-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-amide trifluoroacetate

Guidance literature:

With triethylamine; In dichloromethane; isopropyl alcohol; at 20 ℃;

upstream raw materials:

4-amino-1-(pyridin-2-yl)piperidine

1,1'-carbonyldiimidazole

Downstream raw materials:

6-[(2,2-Diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-N-(2-[({[1-(2-pyridinyl)-4-piperidinyl]amino}carbonyl)amino]ethyl)-9H-purine-2-carboxamide

N-[(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-{2-[3-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-ureido]-ethylamino}-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide trifluoroacetate

[(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-{2-[3-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-ureido]-ethylcarbamoyl}-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-carbamic acid tert-butyl ester

9-{(3AR,4R,6S,6AS)-6-[(ethylamino)carbonyl]-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl}-6-[(2,2-diphenylethyl)amino]-N-{2-[({[1-(2-pyridinyl)-4-piperidinyl]amino}carbonyl)amino]ethyl}-9H-purine-2-carboxamide