1-(2-Pyridinyl)-4-piperidinamine

Base Information

• Chemical Name: 1-(2-Pyridinyl)-4-piperidinamine
• CAS No.: 144465-94-1
• Molecular Formula: C10H15 N3
• Molecular Weight: 177.249
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60436629
• Wikidata: Q72504379
• ChEMBL ID: CHEMBL4552093
• Mol file: 144465-94-1.mol

Synonyms:144465-94-1;1-(Pyridin-2-yl)piperidin-4-amine;1-(2-Pyridinyl)-4-piperidinamine;1-pyridin-2-ylpiperidin-4-amine;(1-Pyridin-2-yl)piperidin-4-amine;3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-ylamine;4-Piperidinamine, 1-(2-pyridinyl)-;1-(2-pyridyl)piperidin-4-amine;3,4,5,6-Tetrahydro-2H-(1,2')bipyridinyl-4-ylamine;SCHEMBL243658;CHEMBL4552093;DTXSID60436629;CZINLSYKXBADTA-UHFFFAOYSA-N;MFCD08061082;AKOS000195353;AM84261;CS-W006834;FS-3717;SB33655;BB 0262527;FT-0648395;EN300-40358;1-(2-pyridinyl)-4-piperidinamine, AldrichCPR;F13517;J-500262;F2167-0833

Chemical Property of 1-(2-Pyridinyl)-4-piperidinamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 318.7°Cat760mmHg
• PKA: 9.90±0.20(Predicted)
• Flash Point: 146.6°C
• PSA: 42.15000
• Density: 1.09g/cm³
• LogP: 1.77440
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.126597491
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

98%min ^*data from raw suppliers

3,4,5,6-Tetrahydro-2H-[1,2'']bipyridinyl-4-ylamine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1N)C2=CC=CC=N2
• Uses: 1-(2-Pyridinyl)-4-piperidinamine is used in the preparation of peripherally selective cannabinoid-1 (CB1) receptor agonists.

Technology Process of 1-(2-Pyridinyl)-4-piperidinamine

There total 7 articles about 1-(2-Pyridinyl)-4-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid tert-butyl ester (252578-12-4) → 4-amino-1-(pyridin-2-yl)piperidine (144465-94-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

2-bromo-pyridine (109-04-6) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 4-amino-1-(pyridin-2-yl)piperidine (144465-94-1)

Guidance literature:

With nitrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; hexane; ethyl acetate;

Reference yield:

(3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-yl)-carbamic acid tert-butyl ester (441330-00-3) → 4-amino-1-(pyridin-2-yl)piperidine (144465-94-1)

Guidance literature:

With hydrogenchloride; In methanol;

upstream raw materials:

(3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid tert-butyl ester

(3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-yl)-carbamic acid tert-butyl ester

2-bromo-pyridine

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-benzamide

1H-imidazole

N-(1-(pyridin-2-yl)piperidin-4-yl)-1H-imidazole-1-carboxamide

Refernces

• 1、 -. "4- (4-CYANOPHENYL) -1- (3-TRIFLUOROMETHYLPHENYL) -3,4, 6, 7-TETRAHYDRO-1H-PYRROLO [3, 4- D] PYRIMIDINE-2, 5-DIONE DERIVATIVES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS". Page/Page column 15-16. . Retrieved 2009/06/27.
• 2、 -. "PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)". Page 60. . Retrieved 2010/11/30.