1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

Base Information

Chemical Name:1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione
CAS No.:1338576-04-7
Molecular Formula:C₁₈H₁₄N₂O₇S
Molecular Weight:402.384
Hs Code.:

Synonyms:1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

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Chemical Property of 1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

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Technology Process of 1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

There total 3 articles about 1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1338575-85-1
tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

: 1338576-04-7
1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

Guidance literature:: tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium acetate; In acetic anhydride; for 6h; Reflux;
DOI:10.1021/ol202436a

Reference yield:

: 1094677-68-5
methyl 2-(5'-tert-butoxy-5'-oxopent-1'-en-2'-yl)benzoate

: 1338576-04-7
1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 6 h / Reflux

With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/ol202436a

Reference yield:

: 92975-38-7
4-bromo-4-pentenoic acid tert-butyl ester

: 1338576-04-7
1'-((4-nitrophenyl)sulfonyl)-3H-spiro[isobenzofuran-1,3'-piperidine]-3,6'-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C

3.2: 6 h / Reflux

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/ol202436a