tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Base Information

Chemical Name:tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate
CAS No.:1338575-85-1
Molecular Formula:C₂₂H₂₄N₂O₈S
Molecular Weight:476.507
Hs Code.:

Synonyms:tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Suppliers and Price of tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

There total 3 articles about tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1094677-68-5
methyl 2-(5'-tert-butoxy-5'-oxopent-1'-en-2'-yl)benzoate

: 6325-93-5
p-nitrobenzenesulfonamide

: 1338575-85-1
tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Guidance literature:: methyl 2-(5'-tert-butoxy-5'-oxopent-1'-en-2'-yl)benzoate; With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In acetonitrile; at 20 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

p-nitrobenzenesulfonamide; With iodosylbenzene; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol202436a

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 1338575-85-1
tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane / 16 h / Inert atmosphere; Reflux

3.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1021/ol202436a

Reference yield:

: 92975-38-7
4-bromo-4-pentenoic acid tert-butyl ester

: 1338575-85-1
tert-butyl 3-(1-((4-nitrophenylsulfonamido)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1021/ol202436a