Multi-step reaction with 7 steps
1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C
2.2: 20 °C
3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C
4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C
4.2: 0.08 h
4.3: 0 - 20 °C
5.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 20 °C
6.1: sodium hydrogencarbonate; sodium iodide / acetonitrile / 60 °C
7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; palladium 10% on activated carbon; ammonium formate; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium iodide;
In
1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.12.109