(S)-benzyl 3-aminopiperidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 3-aminopiperidine-1-carboxylate
CAS No.:876461-55-1
Molecular Formula:C13H18 N2 O2
Molecular Weight:234.298
Hs Code.:29333990
DSSTox Substance ID:DTXSID60363800
Wikidata:Q72441042
Mol file:876461-55-1.mol

Synonyms:876461-55-1;(S)-benzyl 3-aminopiperidine-1-carboxylate;(S)-1-Cbz-3-aminopiperidine;(S)-3-Amino-1-Cbz-piperidine;benzyl (3S)-3-aminopiperidine-1-carboxylate;MFCD08061980;Benzyl (S)-3-aminopiperidine-1-carboxylate;(3S)-3-Amino-1-Cbz-piperidine;(S)-Benzyl3-aminopiperidine-1-carboxylate;SCHEMBL12791106;DTXSID60363800;AKOS015836883;CS-W021176;DS-1839;AC-29150;AM804466;1-Piperidinecarboxylicacid,3-amino-,phenylmethyl ester,(3S)-

Suppliers and Price of (S)-benzyl 3-aminopiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
(S)-3-Amino-1-Cbz-piperidine 95+%
1g
$ 260.00

Synthonix
(S)-3-Amino-1-Cbz-piperidine 95+%
250mg
$ 80.00

Frontier Specialty Chemicals
(S)-3-Amino-1-Cbz-piperidine 98%
250mg
$ 83.00

Frontier Specialty Chemicals
(S)-3-Amino-1-Cbz-piperidine 98%
1g
$ 208.00

Crysdot
(S)-Benzyl3-aminopiperidine-1-carboxylate 97%
10g
$ 254.00

Chemenu
(S)-3-Amino-1-Cbz-piperidine 95+%
5g
$ 153.00

Chemenu
(S)-3-Amino-1-Cbz-piperidine 95+%
10g
$ 234.00

Chemenu
(S)-3-Amino-1-Cbz-piperidine 95+%
25g
$ 514.00

AstaTech
(S)-1-CBZ-3-AMINOPIPERIDINE 97%
5 / G
$ 317.00

AstaTech
(S)-1-CBZ-3-AMINOPIPERIDINE 97%
1 / G
$ 85.00

Total 35 raw suppliers

Chemical Property of (S)-benzyl 3-aminopiperidine-1-carboxylate

Chemical Property:

Boiling Point:367.2±42.0 °C(Predicted)
PKA:10.33±0.20(Predicted)
PSA：55.56000
Density:1.151±0.06 g/cm3(Predicted)
LogP:2.38450
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:234.136827821
Heavy Atom Count:17
Complexity:252

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Amino-1-Cbz-piperidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN(C1)C(=O)OCC2=CC=CC=C2)N
Isomeric SMILES:C1C[C@@H](CN(C1)C(=O)OCC2=CC=CC=C2)N

Technology Process of (S)-benzyl 3-aminopiperidine-1-carboxylate

There total 3 articles about (S)-benzyl 3-aminopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

: 876461-55-1
(S)-benzyl 3-aminopiperidine-1-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 876461-55-1
(S)-benzyl 3-aminopiperidine-1-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 876461-55-1
(S)-benzyl 3-aminopiperidine-1-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.12.109