phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate

Base Information

• Chemical Name: phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate
• CAS No.: 1610565-95-1
• Molecular Formula: C₁₇H₁₁F₃N₂O₂S
• Molecular Weight: 364.348
• Mol file: 1610565-95-1.mol

Synonyms:phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate

Chemical Property of phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate

There total 2 articles about phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-phenyl-2-(trifluoromethyl)thiazol-5-amine + phenyl chloroformate (1885-14-9) → phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate (1610565-95-1)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate; at 20 ℃; for 23h;

Reference yield:

N-(cyano(phenyl)methyl)-2,2,2-trifluoroacetamide (39149-35-4) → phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate (1610565-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawessons reagent / toluene / 24 h / 100 °C

2: sodium hydroxide / ethyl acetate; water / 23 h / 20 °C

With Lawessons reagent; sodium hydroxide; In water; ethyl acetate; toluene;

Reference yield: 13.0%

3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-4-methyl-1-phenyl-1H-pyrazol-5-amine (1414568-91-4) + phenyl (4-phenyl-2-(trifluoromethyl)thiazol-5-yl)carbamate (1610565-95-1) → 1-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(4-phenyl-2-(trifluoromethyl)thiazol-5-yl)urea (1610565-96-2)

Guidance literature:

In isopropyl alcohol; at 50 ℃; for 24h;

upstream raw materials:

phenyl chloroformate

N-(cyano(phenyl)methyl)-2,2,2-trifluoroacetamide

Downstream raw materials:

1-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(4-phenyl-2-(trifluoromethyl)thiazol-5-yl)urea

1-(3-(2-hydroxyethoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(4-phenyl-2-(trifluoromethyl)thiazol-5-yl)urea