1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

Base Information

Chemical Name:1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine
CAS No.:1341232-44-7
Molecular Formula:C₁₅H₁₃ClFN₃
Molecular Weight:289.74
Hs Code.:

Synonyms:1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

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Chemical Property of 1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

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Technology Process of 1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

There total 8 articles about 1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1341232-43-6
1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanone

: 1341232-44-7
1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

Guidance literature:: With ammonium acetate; sodium cyanoborohydride; In methanol; at 65 ℃;

Reference yield:

: 67754-03-4
methyl 2,5-dichloronicotinate

: 1341232-44-7
1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 14.5 h / 80 °C / Inert atmosphere

2.1: mesitylenesulfonylhydroxylamine / diethyl ether; acetonitrile / 24 h / 20 °C

2.2: 5.25 h / 20 °C

3.1: trifluoroacetic acid / 2 h / 60 °C

4.1: water; lithium hydroxide monohydrate / methanol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.2: 0 °C

7.1: sodium cyanoborohydride; ammonium acetate / methanol / 65 °C

With lithium hydroxide monohydrate; ammonium acetate; water; mesitylenesulfonylhydroxylamine; sodium cyanoborohydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 59782-85-3
2,5-dichloronicotinic acid

: 1341232-44-7
1-[4-chloro-7-(3-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]ethanamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 18 h / 20 °C

1.2: 0.5 h / 0 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 14.5 h / 80 °C / Inert atmosphere

3.1: mesitylenesulfonylhydroxylamine / diethyl ether; acetonitrile / 24 h / 20 °C

3.2: 5.25 h / 20 °C

4.1: trifluoroacetic acid / 2 h / 60 °C

5.1: water; lithium hydroxide monohydrate / methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

7.2: 0 °C

8.1: sodium cyanoborohydride; ammonium acetate / methanol / 65 °C

With oxalyl dichloride; lithium hydroxide monohydrate; ammonium acetate; water; mesitylenesulfonylhydroxylamine; sodium cyanoborohydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;