67754-03-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2,5-DICHLORONICOTINATE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of new chemical entities, contributing to drug discovery and development.
Used in Agrochemical Industry:
METHYL 2,5-DICHLORONICOTINATE is used as a building block in the development of novel herbicides and pesticides. Its potential application in this field is currently being studied, with the aim of enhancing the effectiveness of these products.

InChI:InChI=1/C7H5Cl2NO2/c1-12-7(11)5-2-4(8)3-10-6(5)9/h2-3H,1H3

Upstream product

• 38076-80-1 5-chloro-2-hydroxypyridine-3-carboxylic acid 
• 67-56-1 methanol 

Downstream Products

• 558465-93-3 (2,5-dichloro-3-pyridinyl)methanol 
• 50735-33-6 methyl 2-amino-5-chloro-3-pyridinecarboxylate 
• 478834-13-8 5-chloro-2-{2-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-nicotinic acid methyl ester 
• 367500-94-5 8-chloro-5-(3-fluorophenyl)-3-methylimidazo[1,5-a]pyridine-6-carboxylic acid 
• 1341232-04-9 methyl 6-[(acetylamino)methyl]-5-chloro-2-(3-fluorophenyl)nicotinate 

Relevant academic research and scientific papers

SUBSTITUTED NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES

Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: (Ia), (Ib), (Ic), (Id) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R, R1, R2, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.