(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

Base Information

Chemical Name:(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide
CAS No.:1332333-01-3
Molecular Formula:C₂₅H₂₅FN₆O₂
Molecular Weight:460.511
Hs Code.:

Synonyms:(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

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Chemical Property of (3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

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Technology Process of (3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

There total 6 articles about (3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: N,N-dimethylaminocarbamoyl chloride

: 1332333-92-2
1,1-dimethylethyl(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-1-pyrrolidinecarboxylate

: 1332333-01-3
(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

Guidance literature:: 1,1-dimethylethyl(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-1-pyrrolidinecarboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h; Capped vial;

N,N-dimethylaminocarbamoyl chloride; With diethylamine; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h; Capped vial;

Reference yield:

: 204688-61-9
2‐[(3S)‐1‐[(tert‐butoxy)carbonyl]pyrrolidin‐3‐yl]acetic acid

: 1332333-01-3
(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / diethyl ether; ethanol / 20 °C

2.1: hydrazine hydrate / ethanol / 80 °C

3.1: dichloromethane / 0.5 h / 0 - 20 °C

4.1: potassium carbonate / isopropyl alcohol; water / 16 h / 140 °C

4.2: 20 °C

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 110 °C / Inert atmosphere; Sealed tube

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Capped vial

6.2: 2 h / 20 °C / Capped vial

With hydrogenchloride; potassium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1332333-24-0
1,1-dimethylethyl (3S)-3-(2-hydrazino-2-oxoethyl)-1-pyrrolidinecarboxylate

: 1332333-01-3
(3S)-3-({4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)-N,N-dimethyl-1-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0.5 h / 0 - 20 °C

2.1: potassium carbonate / isopropyl alcohol; water / 16 h / 140 °C

2.2: 20 °C

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 110 °C / Inert atmosphere; Sealed tube

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Capped vial

4.2: 2 h / 20 °C / Capped vial

With hydrogenchloride; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol;