1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane

Base Information

• Chemical Name: 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane
• CAS No.: 936917-36-1
• Molecular Formula: C₈H₁₆IN₃O₃
• Molecular Weight: 329.138

Synonyms:1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane

Chemical Property of 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Iodo-PEG3-azide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Iodo-PEG3-Azide is a PEG linker containing iodide and azide moieties. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The iodide is a very good leaving group for nucleophilic substitution reactions.

Technology Process of 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane

There total 5 articles about 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

11-azide-1-{(methylsulfonyl)oxy}-3,6,9-trioxaundecane (134179-43-4) → 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane (936917-36-1)

Guidance literature:

With sodium iodide; In acetone; at 65 ℃; for 15h;

DOI:10.1039/c2ob26968f

Reference yield: 80.0%

1,11-diiodo-3,6-9-trioxaundecane (36839-56-2) → 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane (936917-36-1)

Guidance literature:

With sodium azide; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2019.111859

Reference yield:

Tetraethylene glycol (112-60-7) → 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane (936917-36-1)

Guidance literature:

Multi-step reaction with 4 steps

1: silver(l) oxide / dichloromethane / 24 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C

3: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

4: sodium iodide / acetone / 15 h / 65 °C

With sodium azide; triethylamine; sodium iodide; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1039/c2ob26968f

upstream raw materials:

1,11-diiodo-3,6-9-trioxaundecane

11-azide-1-{(methylsulfonyl)oxy}-3,6,9-trioxaundecane

Tetraethylene glycol

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate

Downstream raw materials:

N-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethyl)-N-[4-(2,4,6-trimethyl-phenyl)-thiazol-2-yl]benzamide

C₁₉H₃₀N₄O₆

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 936917-36-1 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane

Send

Send

Metric Ton KG G Pound L ML

Send

Send