methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate

Base Information

• Chemical Name: methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate
• CAS No.: 1036387-99-1
• Molecular Formula: C₃₃H₃₇FN₄O₈S
• Molecular Weight: 668.743
• Mol file: 1036387-99-1.mol

Synonyms:methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate

Chemical Property of methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate

There total 1 articles about methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.7%

(R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride (900174-71-2) + C18H17FN2O5 (1036389-92-0) → methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate (1036387-99-1) + methyl 3-((R)-1-((S)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate (1036391-04-4)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 15h;

upstream raw materials:

(R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride

C₁₈H₁₇FN₂O₅