2,2-Dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid

Base Information

Chemical Name:2,2-Dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid
CAS No.:121925-12-0
Molecular Formula:C₁₁H₁₂O₄
Molecular Weight:208.214
Hs Code.:
European Community (EC) Number:898-969-5

Synonyms:SCHEMBL14898030;EN300-27114876;Z4607508458;2,2-dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid;121925-12-0

Suppliers and Price of 2,2-Dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:208.07355886
Heavy Atom Count:15
Complexity:261

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(OCC2=C(O1)C=C(C=C2)C(=O)O)C

Technology Process of 2,2-Dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid

There total 3 articles about 2,2-Dimethyl-2,4-dihydro-1,3-benzodioxine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 71780-41-1
methyl 2,2-dimethyl-2H,4H-1,3-benzodioxine-7-carboxylate

: 121925-12-0
2,2-dimethyl-2H,4H-1,3-benzodioxine-7-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;
DOI:10.1021/acs.jmedchem.9b01689

Reference yield:

: 71780-40-0
methyl 3-hydroxy-4-(hydroxymethyl)-benzoate

: 121925-12-0
2,2-dimethyl-2H,4H-1,3-benzodioxine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / acetone / 3 h / 20 °C

2: lithium hydroxide; water / 4 h / 20 °C

With water; toluene-4-sulfonic acid; lithium hydroxide; In acetone;

Reference yield:

: 24589-98-8
methyl 4-formyl-3-hydroxybenzoate

: 121925-12-0
2,2-dimethyl-2H,4H-1,3-benzodioxine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

2: toluene-4-sulfonic acid / acetone / 3 h / 20 °C

3: lithium hydroxide; water / 4 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; toluene-4-sulfonic acid; lithium hydroxide; In methanol; acetone;