24589-98-8

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-FORMYL-3-HYDROXYBENZOATE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
METHYL 4-FORMYL-3-HYDROXYBENZOATE serves as a valuable building block in the synthesis of a wide range of organic compounds, including dyes, pigments, and other specialty chemicals. Its versatility in chemical reactions makes it a useful starting material for the creation of various products.
Used in Research and Development:
Due to its unique structure and potential applications, METHYL 4-FORMYL-3-HYDROXYBENZOATE is often utilized in research and development settings. Scientists and researchers use METHYL 4-FORMYL-3-HYDROXYBENZOATE to study its properties, explore its potential applications, and develop new methods for its synthesis and use.
Used in the Preparation of Enzyme Inhibitors:
METHYL 4-FORMYL-3-HYDROXYBENZOATE is used as a starting material in the preparation of α-glucosidase inhibitors and β-lactamase substrates. These inhibitors and substrates have potential applications in the development of new drugs for the treatment of various diseases, including diabetes and bacterial infections.

InChI:InChI=1/C9H8O4/c1-13-9(12)6-2-3-7(5-10)8(11)4-6/h2-5,11H,1H3

Upstream product

• 67-56-1 methanol 
• 619-12-5 4-formyl-3-hydroxybenzoic acid 
• 100-97-0 hexamethylenetetramine 
• 19438-10-9 methyl 3-hydroxybenzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 99-06-9 3-Carboxyphenol 
• 50-00-0 formaldehyd 
• 76-05-1 trifluoroacetic acid 
• 636-94-2 2-hydroxyterephthalic acid 
• 586-35-6 2-bromo-1,4-benzenedicarboxylic acid 
• 157942-12-6 methyl 3-hydroxy-4-iodobenzoate 
• 67-71-0 dimethylsulfone 
• 1560893-80-2 methyl 3-hydroxy-4-vinylbenzoate 
• 6342-72-9 dimethyl hydroxyterephthalate 

Downstream Products

• 77095-51-3 benzofuran-6-carboxylic acid 
• 908296-34-4 4-formyl-3-{[2-(2-naphthalenyl)ethyl]oxy}benzoic acid methyl ester 
• 360775-63-9 methyl 4-(4-ethylbenzyl)-3-hydroxybenzoate 
• 360775-67-3 C₁₇H₁₈O₅ 
• 360776-08-5 C₁₇H₁₈O₄ 
• 360775-65-1 C₁₈H₁₈O₅ 
• 1610861-25-0 (Z)-3-(cyclopropylmethoxy)-4-((methoxyimino)methyl)benzoic acid 
• 1610861-95-4 methyl 3-(benzyloxy)-4-(morpholinomethyl)benzoate 
• 87177-50-2 3-hydroxy-4-morpholin-4-ylmethylbenzoic acid methyl ester 
• 1610861-94-3 methyl 3-(methylsulfonyloxy)-4-(morpholinomethyl)benzoate 
• 1610861-93-2 3-(methylsulfonyloxy)-4-(morpholinomethyl)benzoic acid 
• 1610861-92-1 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(methylsulfonyloxy)-4-(morpholinomethyl)-benzoyloxy)ethyl)pyridine 1-oxide 
• 74733-24-7 4-formyl-3-methoxybenzoic acid methyl ester 
• 527681-26-1 methyl 3-allyloxy-4-formylbenzoate 

Relevant academic research and scientific papers

Selective and one-pot formation of phenols by anodic oxidation

Direct monohydroxylation of benzene and substituted benzenes was successfully performed by anodic oxidation to form the corresponding phenol derivatives in good yields. The anodic oxidation was generally carried out in a mixed solvent of trifluoroacetic acid and dichloromethane containing triethylamine using a divided cell equipped with a platinum plate as the anode, a carbon rod as the cathode. Benzene derivatives having electron withdrawing groups were suitable for the present electrochemical oxidation. It was clarified that aryltrifluoroacetates were formed as the initial products from the reaction of the radical cations, generated by one electron transfer from the substrates, with trifluoroacetic acid, followed by hydrolysis during work-up to give the corresponding phenols.

Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.

Preparation method of benzofuran derivative

The invention discloses a preparation method for synthesizing a benzofuran derivative. The specific implementation method is as shown in the specification. The method has novel synthetic route, simpleand convenient operation, high yield, and good safety, and is suitable for industrial production. A novel synthetic method of an intermediate VI is also designed, a Wittig reaction is carried out, and then ring-closing is carried out to obtain a benzofuran ring.

Synthesis method of methyl 4-formyl-3-hydroxybenzoate

The invention discloses a synthesis method of methyl 4-formyl-3-hydroxybenzoate. The method includes the following step that methyl 3-hydroxybenzoate as a raw materials reacts with paraformaldehyde under the action of Lewis acid and an organic base to obt

Fullerene-Filled Liquid-Crystal Stars: A Supramolecular Click Mechanism for the Generation of Tailored Donor–Acceptor Assemblies

Two shape-persistent star mesogens with oligo(phenylene ethenylene) arms and a phthalocyanine core—one providing free space (2) and one sterically encumbered by four fullerenes attached through spacers (3)—have been successfully synthesized. In contrast to the smaller discotic derivative 1, mesogen 2 forms a columnar liquid crystal (LC), which can only be partially aligned without π-stacking, while 3 is not an LC. Exceptionally, the 1:1 mixture of 2 and 3 forms an alignable columnar LC with strong π-stacking and quadruply helically organized fullerenes by an unprecedented click process that is similar to a ball detent mechanism. The C60 units also interconnect different columns. This is driven by nanosegregation and space-filling of the voids with fullerenes. Photophysical studies confirm the presence of a light-collecting system that generates charge-separated states in solution and in the solid state, which makes such highly organized materials attractive for the study of future photovoltaic devices.

PROCESSES FOR PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE

Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

HDAC6 INHIBITORS AND IMAGING AGENTS

Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prep

NMDA RECEPTOR MODULATORS AND USES RELATED THERETO

This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds disclosed herein are NR2C subunit-selective NMDA potentiators. In certain embodiments, the disclosure contemplates compounds and pharmaceutical compositions. In certain embodiments, the disclosure contemplates compounds disclosed herein as prodrugs, optionally substituted with one or more substituents, derivatives, or salts thereof. In certain embodiments, the disclosure relates to methods of treating or preventing nervous system disorders comprising administering an effective amount of a composition comprising compound disclosed herein to a subject in need thereof.

1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators

NMDA receptors are tetrameric complexes composed of GluN1 and GluN2A-D subunits that mediate a slow Ca2+-permeable component of excitatory synaptic transmission. NMDA receptors have been implicated in a wide range of neurological diseases and thus represent an important therapeutic target. We herein describe a novel series of pyrrolidinones that selectively potentiate only NMDA receptors that contain the GluN2C subunit. The most active analogues tested were over 100-fold selective for recombinant GluN2C-containing receptors over GluN2A/B/D-containing NMDA receptors as well as AMPA and kainate receptors. This series represents the first class of allosteric potentiators that are selective for diheteromeric GluN2C-containing NMDA receptors.