[4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

Base Information

Chemical Name:[4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone
CAS No.:1443757-55-8
Molecular Formula:C₂₃H₂₅N₇O₂
Molecular Weight:431.497
Hs Code.:

Synonyms:[4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

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Chemical Property of [4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

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Technology Process of [4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

There total 10 articles about [4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 54798-92-4
2-phenyl-2H-tetrazole-5-carboxylic acid

: 1443759-04-3
(6-cyclopropyl-pyridin-2-yl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate

: 1443757-55-8
[4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 21190-88-5
6-bromopyridine-2-carboxylic acid ethyl ester

: 1443757-55-8
[4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / toluene / 13 h / 100 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

4.1: hydrogen; palladium on activated charcoal / methanol / 5 h / 20 °C

4.2: 12 h / 20 °C

5.1: 3.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; palladium on activated charcoal; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1443758-98-2
4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester

: 1443757-55-8
[4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(2-phenyl-2H-tetrazol-5-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium on activated charcoal / methanol / 5 h / 20 °C

1.2: 12 h / 20 °C

2.1: 3.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

With palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;