benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

Base Information

Chemical Name:benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate
CAS No.:603121-69-3
Molecular Formula:C₂₈H₃₂N₂O₅
Molecular Weight:476.572
Hs Code.:

Synonyms:benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

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Technology Process of benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

There total 1 articles about benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2899-07-2
(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 603121-69-3
benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ejoc.200200705

Reference yield: 83.6%

: 603121-69-3
benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

: 336878-28-5
(2S)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(methylamino)-3-phenylpropanamide

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; at 50 ℃; for 2h;
DOI:10.1002/ejoc.200200705

Reference yield:

: 603121-69-3
benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl(methyl)carbamate

: (3S,11bR)-3,11b-dibenzyl-9,10-dimethoxy-2-methyl-7,11b-dihydro-2H-pyrazino[2,1-a]isoquinoline-1,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 83.6 percent / HCl; H₂ / Pd/C / ethanol; H₂O / 2 h / 50 °C

2: 55 percent / Et₃N; BOP / tetrahydrofuran / 20 °C

3: acetyl chloride / methanol / 336 h / 0 °C

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; 3: Pictet-Spengler cyclization;
DOI:10.1002/ejoc.200200705