(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate

Base Information

• Chemical Name: (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate
• CAS No.: 881920-98-5
• Molecular Formula: C₂₂H₃₃NO₂
• Molecular Weight: 343.51
• Mol file: 881920-98-5.mol

Synonyms:(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate

Chemical Property of (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate

There total 4 articles about (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,2,2-Trichloro-acetyl)-carbamic acid (E)-(R)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-4-phenyl-but-2-enyl ester → (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate (881920-98-5)

Guidance literature:

With potassium carbonate; In methanol; water; at 0 - 23 ℃;

DOI:10.1021/ol053061g

Reference yield:

(E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-one (881920-92-9) → (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate (881920-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 125 mg / lithium triethylborohydride / tetrahydrofuran / 0.33 h / -78 °C

2: CH₂Cl₂ / 1 h / 0 °C

3: 125 mg / potassium carbonate / methanol; H₂O / 0 - 23 °C

With lithium triethylborohydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/ol053061g

Reference yield:

(R,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol (289909-72-4) → (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenylbut-2-enyl carbamate (881920-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 0 °C

2: 125 mg / potassium carbonate / methanol; H₂O / 0 - 23 °C

With potassium carbonate; In methanol; dichloromethane; water;

DOI:10.1021/ol053061g

upstream raw materials:

(E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-one

(S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol

(R,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol