(S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol

Base Information

• Chemical Name: (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol
• CAS No.: 289909-48-4
• Molecular Formula: C₂₁H₃₂O
• Molecular Weight: 300.484
• Mol file: 289909-48-4.mol

Synonyms:(S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol

Chemical Property of (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol

There total 2 articles about (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

propargyl benzene (10147-11-2) + trimethylaluminum (75-24-1) + (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde (80434-59-9,485843-44-5,796865-68-4) → (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol (289909-48-4) + (R,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol (289909-72-4)

Guidance literature:

trimethylaluminum; With zirconocene dichloride; In dichloromethane;

propargyl benzene; In dichloromethane; at 20 ℃; for 16h;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; In tetrahydrofuran; dichloromethane; at -50 - -10 ℃; for 3h;

DOI:10.1021/ja046084j

Reference yield:

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde (80434-59-9,485843-44-5,796865-68-4) + C12H17Al → (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol (289909-48-4) + (R,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol (289909-72-4)

Guidance literature:

In dichloromethane;

DOI:10.1002/1521-3773(20000602)39:11<1930::AID-ANIE1930>3.0.CO;2-J

Reference yield: 88.0%

pivaloyl chloride (3282-30-2) + (S,E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-ol (289909-48-4) → 2,2-Dimethyl-propionic acid (E)-(S)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-4-phenyl-but-2-enyl ester (474105-91-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ja046084j

upstream raw materials:

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

propargyl benzene

trimethylaluminum

Downstream raw materials:

2,2-Dimethyl-propionic acid (E)-(S)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-4-phenyl-but-2-enyl ester

(E)-3-benzyl-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)but-2-en-1-one

C₂₈H₃₈OS

C₂₈H₃₈SO₃