(1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene

Base Information

• Chemical Name: (1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene
• CAS No.: 294660-47-2
• Molecular Formula: C₁₇H₁₈N₂
• Molecular Weight: 250.343
• Mol file: 294660-47-2.mol

Synonyms:(1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene

Chemical Property of (1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene

There total 2 articles about (1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzamidine monohydrochloride (1670-14-0) + (1S,5R)-2-(1-chloro-(E)-ethylidene)-6,6-dimethylbicyclo[3.1.0]hexan-3-one (340165-15-3) → (1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene (294660-47-2)

Guidance literature:

benzamidine monohydrochloride; (1S,5R)-2-(1-chloro-(E)-ethylidene)-6,6-dimethylbicyclo[3.1.0]hexan-3-one; With sodium hydrogencarbonate; In methanol; at 20 ℃; for 5h;

In methanol; for 2h; Heating;

DOI:10.1081/SCC-100000204

Reference yield:

(1R,5R)-2-Acetyl-6,6-dimethyl-bicyclo[3.1.0]hexan-3-one (197440-66-7) → (1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene (294660-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / Ph₃P; CCl₄ / CHCl₃ / 4 h / Heating

2.1: NaHCO₃ / methanol / 5 h / 20 °C

2.2: 86 percent / methanol / 2 h / Heating

With tetrachloromethane; sodium hydrogencarbonate; triphenylphosphine; In methanol; chloroform;

DOI:10.1081/SCC-100000204

Reference yield: 58.0%

(1aR,6aR)-1,1,2-trimethyl-4-phenyl-1,1a,6,6a-tetrahydro-3,5-diaza-cyclopropa[a]indene (294660-47-2) → 4,6,6-trimethyl-2-phenyl-5,6-dihydro-quinazoline

Guidance literature:

With potassium hydroxide; In methanol; for 20h; Heating;

DOI:10.1081/SCC-100000204

upstream raw materials:

benzamidine monohydrochloride

(1S,5R)-2-(1-chloro-(E)-ethylidene)-6,6-dimethylbicyclo[3.1.0]hexan-3-one

(1R,5R)-2-Acetyl-6,6-dimethyl-bicyclo[3.1.0]hexan-3-one