3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Chemical Name:3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS No.:1259536-64-5
Molecular Formula:C₁₉H₁₉F₃N₄O
Molecular Weight:376.381
Hs Code.:

Synonyms:3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Chemical Property of 3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Technology Process of 3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

There total 4 articles about 3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-89-4
piperidine

: 1259536-57-6
5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

: 1259536-64-5
3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 1h;
DOI:10.1016/j.ejmech.2011.01.010

Reference yield:

: 140-29-4
phenylacetonitrile

: 1259536-64-5
3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; sodium / 2 h / 50 °C / Reflux

2: hydrazinium sulfate / carbonic acid dimethyl ester / 4 h / 80 °C / Molecular sieve

3: acetic acid / 4 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

With ethanol; sodium; potassium carbonate; acetic acid; hydrazinium sulfate; In N,N-dimethyl-formamide; carbonic acid dimethyl ester;
DOI:10.1016/j.ejmech.2011.01.010

Reference yield:

: 1259536-96-3
C₁₀H₅F₃NO^(1-)*Na⁽¹⁺⁾

: 1259536-64-5
3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazinium sulfate / carbonic acid dimethyl ester / 4 h / 80 °C / Molecular sieve

2: acetic acid / 4 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

With potassium carbonate; acetic acid; hydrazinium sulfate; In N,N-dimethyl-formamide; carbonic acid dimethyl ester;
DOI:10.1016/j.ejmech.2011.01.010