5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Base Information

• Chemical Name: 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
• CAS No.: 1259536-57-6
• Molecular Formula: C₁₄H₉ClF₃N₃O
• Molecular Weight: 327.693

Synonyms:5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Chemical Property of 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Technology Process of 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

There total 3 articles about 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl (2-chloroaceto)acetate (638-07-3) + 4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (62649-36-9) → 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (1259536-57-6)

Guidance literature:

With acetic acid; for 4h; Reflux;

DOI:10.1016/j.ejmech.2011.01.010

Reference yield:

C10H5F3NO(1-)*Na(1+) (1259536-96-3) → 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (1259536-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazinium sulfate / carbonic acid dimethyl ester / 4 h / 80 °C / Molecular sieve

2: acetic acid / 4 h / Reflux

With acetic acid; hydrazinium sulfate; In carbonic acid dimethyl ester;

DOI:10.1016/j.ejmech.2011.01.010

Reference yield:

phenylacetonitrile (140-29-4) → 5-(chloromethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (1259536-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol; sodium / 2 h / 50 °C / Reflux

2: hydrazinium sulfate / carbonic acid dimethyl ester / 4 h / 80 °C / Molecular sieve

3: acetic acid / 4 h / Reflux

With ethanol; sodium; acetic acid; hydrazinium sulfate; In carbonic acid dimethyl ester;

DOI:10.1016/j.ejmech.2011.01.010

upstream raw materials:

C₁₀H₅F₃NO^(1-)*Na⁽¹⁺⁾

ethyl (2-chloroaceto)acetate

4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine

phenylacetonitrile

Downstream raw materials:

3-phenyl-5-(piperidin-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

5-aminomethyl-3-phenyl-2-trifluoromethyl-pyrazole[1,5-a]pyrimidin-7(4H)-one

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