methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester
CAS No.:349458-79-3
Molecular Formula:C₂₃H₂₄O₁₂S₂
Molecular Weight:556.568
Hs Code.:

Synonyms:methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

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Chemical Property of methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

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Technology Process of methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

There total 7 articles about methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124-63-0
methanesulfonyl chloride

: 349458-75-9
6,7-bis-(2-hydroxy-ethoxy)-3-(4-methoxy-benzoyl)-4a,8a-dihydro-chromen-2-one

: 349458-79-3
methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.333333h;
DOI:10.1016/S0040-4020(01)00168-5

Reference yield:

: 119309-58-9
(2-ethoxycarbonylmethoxy-5-formyl-phenoxy)-acetic acid ethyl ester

: 349458-79-3
methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 71 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

2.1: LiAlH₄ / tetrahydrofuran / 3 h

2.2: 88 percent / sodium hydroxide / tetrahydrofuran / 4 h / Heating

3.1: trifluoroacetic acid / 3 h / 90 °C

3.2: 55 percent / trifluoroacetic acid / H₂O / 4 h / Heating

4.1: 83 percent / piperidine / ethanol / 4 h / Heating

5.1: 94 percent / triethylamine / CH₂Cl₂ / 0.33 h

With piperidine; lithium aluminium tetrahydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; 1.1: Baeyer-Villiger rearrangement / 4.1: Claisen condensation;
DOI:10.1016/S0040-4020(01)00168-5

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 349458-79-3
methanesulfonic acid 2-[7-(2-methanesulfonyloxy-ethoxy)-3-(4-methoxy-benzoyl)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 81 percent / potassium carbonate / acetone / 1 h / Heating

2.1: 71 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 3 h

3.2: 88 percent / sodium hydroxide / tetrahydrofuran / 4 h / Heating

4.1: trifluoroacetic acid / 3 h / 90 °C

4.2: 55 percent / trifluoroacetic acid / H₂O / 4 h / Heating

5.1: 83 percent / piperidine / ethanol / 4 h / Heating

6.1: 94 percent / triethylamine / CH₂Cl₂ / 0.33 h

With piperidine; lithium aluminium tetrahydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetone; 2.1: Baeyer-Villiger rearrangement / 5.1: Claisen condensation;
DOI:10.1016/S0040-4020(01)00168-5