C₃₅H₄₈N₂O₁₀

Base Information

Chemical Name:C₃₅H₄₈N₂O₁₀
CAS No.:817167-06-9
Molecular Formula:C₃₅H₄₈N₂O₁₀
Molecular Weight:656.774
Hs Code.:

C<sub>35</sub>H<sub>48</sub>N<sub>2</sub>O<sub>10</sub>

Synonyms:C₃₅H₄₈N₂O₁₀

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Chemical Property of C₃₅H₄₈N₂O₁₀

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Technology Process of C₃₅H₄₈N₂O₁₀

There total 14 articles about C₃₅H₄₈N₂O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 817167-05-8
(4S)-4-[(4R)-4-benzyl-5-oxotetrahydrofuran-(2R)-2-yl]-4-[bis(tert-butoxycarbonyl)amino]butyric acid

: 146548-59-6
2,4,6-trimethoxy benzyl amine hydrochloride

: 817167-06-9
C₃₅H₄₈N₂O₁₀

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol047879y

Reference yield:

: 817166-96-4
[4-(tert-butyldimethylsilanyloxy)-(1S)-1-(5-oxotetrahydrofuran-(2R)-2-yl)butyl]carbamic acid tert-butyl ester

: 817167-06-9
C₃₅H₄₈N₂O₁₀

Guidance literature:: Multi-step reaction with 6 steps

1: LDA / tetrahydrofuran; hexane / 3.5 h / -78 °C

2: Ac₂O; Et₃N / 1.25 h / Heating

3: 0.790 g / H₂ / Pd/C / ethyl acetate; methanol / 4.25 h

4: 92 percent / DMAP / tetrahydrofuran / 21 h / Heating

5: 78 percent / CrO₃; H₂SO₄ / acetone / 1.5 h / -10 °C

6: 92 percent / 1-HOBt; diisopropylethylamine; HBTU / dimethylformamide / 0 - 20 °C

With chromium(VI) oxide; dmap; sulfuric acid; hydrogen; acetic anhydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetone; 5: Jones oxidation;
DOI:10.1021/ol047879y

Reference yield:

: 5-tert-butoxycarbonylamino-8-(tert-butyl-dimethyl-silanyloxy)-4-oxo-oct-2-enoic acid methyl ester

: 817167-06-9
C₃₅H₄₈N₂O₁₀

Guidance literature:: Multi-step reaction with 9 steps

1: 1.44 g / H₂ / Pd/C / ethyl acetate / 4 h

2: LiAlH(t-BuO)3 / ethanol / 2.5 h / -78 °C

3: 2.909 g / AcOH / toluene / 3 h / Heating

4: LDA / tetrahydrofuran; hexane / 3.5 h / -78 °C

5: Ac₂O; Et₃N / 1.25 h / Heating

6: 0.790 g / H₂ / Pd/C / ethyl acetate; methanol / 4.25 h

7: 92 percent / DMAP / tetrahydrofuran / 21 h / Heating

8: 78 percent / CrO₃; H₂SO₄ / acetone / 1.5 h / -10 °C

9: 92 percent / 1-HOBt; diisopropylethylamine; HBTU / dimethylformamide / 0 - 20 °C

With chromium(VI) oxide; dmap; sulfuric acid; hydrogen; acetic anhydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; lithium tri-t-butoxyaluminum hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 8: Jones oxidation;
DOI:10.1021/ol047879y