C₂₁H₁₇N₃O₂

Base Information

• Chemical Name: C₂₁H₁₇N₃O₂
• CAS No.: 1186403-15-5
• Molecular Formula: C₂₁H₁₇N₃O₂
• Molecular Weight: 343.385
• Mol file: 1186403-15-5.mol

Synonyms:C₂₁H₁₇N₃O₂

Chemical Property of C₂₁H₁₇N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₇N₃O₂

There total 4 articles about C₂₁H₁₇N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-2-(trimethylstannyl)-1H-indole-5-carbonitrile (1028752-21-7) + 4-bromobenzenecarbonitrile (623-00-7) → C21H17N3O2 (1186403-15-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 90 - 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.01.037

Reference yield:

4-iodobenzonitrile (3058-39-7) + (1-(tert-butoxycarbonyl)-5-cyano-1H-indol-2-yl)boronic acid (475102-15-9) → C21H17N3O2 (1186403-15-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/j.bmcl.2009.06.021

Reference yield:

1H-indole-5-carbonitrile (15861-24-2,142396-06-3) → C21H17N3O2 (1186403-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / dichloromethane

2: lithium diisopropyl amide / tetrahydrofuran

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 90 - 100 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 3: |Stille Cross Coupling;

DOI:10.1016/j.ejmech.2017.01.037

upstream raw materials:

4-iodobenzonitrile

(1-(tert-butoxycarbonyl)-5-cyano-1H-indol-2-yl)boronic acid

1H-indole-5-carbonitrile

1-(tert-butoxycarbonyl)-1H-indole-5-carbonitrile

Downstream raw materials:

2-(4-cyanophenyl)-1H-indole-5-carbonitrile

C₂₀H₂₁N₃O₂