N-(3,5-dimethylphenyl)pyrimidin-2-amine

Base Information

Chemical Name:N-(3,5-dimethylphenyl)pyrimidin-2-amine
CAS No.:1148035-06-6
Molecular Formula:C₁₂H₁₃N₃
Molecular Weight:199.255
Hs Code.:
DSSTox Substance ID:DTXSID10698437
Nikkaji Number:J2.722.769D
Wikidata:Q82628646

Synonyms:N-(3,5-dimethylphenyl)pyrimidin-2-amine;1148035-06-6;N-(3,5-DIMETHYLPHENYL)-2-PYRIMIDINAMINE;SCHEMBL7253364;DTXSID10698437;2-(3,5-Dimethylanilino)pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,5-dimethylphenyl)pyrimidin-2-amine

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:199.110947427
Heavy Atom Count:15
Complexity:179

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)NC2=NC=CC=N2)C

Technology Process of N-(3,5-dimethylphenyl)pyrimidin-2-amine

There total 2 articles about N-(3,5-dimethylphenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 108-69-0
3,5-dimethylaminoaniline

: 1148035-06-6
N-(3,5-dimethylphenyl)pyrimidin-2-amine

Guidance literature:: With 2-methylphenylzinc bromide; In acetonitrile; for 5h; Inert atmosphere;
DOI:10.1055/s-0030-1261220

Reference yield: 81.0%

: 109-12-6
2-aminopyrimidine

: 22445-41-6
3,5-dimethylphenyl iodide

: 1148035-06-6
N-(3,5-dimethylphenyl)pyrimidin-2-amine

Guidance literature:: With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ll); potassium carbonate; In tert-butyl alcohol; at 110 ℃; Inert atmosphere;

Reference yield: 51.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 1148035-06-6
N-(3,5-dimethylphenyl)pyrimidin-2-amine

: ethyl 2-(2,6-dimethyl-4-(pyrimidin-2-ylamino)phenyl)-2,2-difluoroacetate

Guidance literature:: With [Ru(MesCO₂)₂(p-cymene)]; sodium carbonate; In toluene; at 120 ℃; for 18h; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1039/c8cc05067h