6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

Base Information

Chemical Name:6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one
CAS No.:1430422-31-3
Molecular Formula:C₂₀H₁₆F₃NO₂
Molecular Weight:359.348
Hs Code.:

Synonyms:6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

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Chemical Property of 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

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Technology Process of 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

There total 6 articles about 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1430422-27-7
6-bromo-4’-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5’(1‘H)-one

: 156545-07-2
3,5-difluorophenylboronic acid

: 1430422-31-3
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 2h;

Reference yield:

: 1430422-24-4
N-(6-bromo-3,3-dimethyl-4-vinylchroman-4-yl)-2-methylpropane-2-sulfinamide

: 1430422-31-3
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 0.5 h / 0 - 20 °C / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.1 h

2.2: 16 h

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 0.67 h / 120 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 80 °C

With hydrogenchloride; Hoveyda-Grubbs catalyst second generation; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol; 4.1: |Suzuki Coupling;

Reference yield:

: 1430422-25-5
6-bromo-3,3-dimethyl-4-vinylchroman-4-amine

: 1430422-31-3
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.1 h

1.2: 16 h

2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 0.67 h / 120 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 80 °C

With Hoveyda-Grubbs catalyst second generation; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; water; 3.1: |Suzuki Coupling;