6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

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Chemical Name:6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine
CAS No.:1430422-30-2
Molecular Formula:C₂₀H₁₇F₃N₂O
Molecular Weight:358.363
Hs Code.:

Synonyms:6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

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Chemical Property of 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

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Technology Process of 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

There total 7 articles about 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1430422-31-3
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one

: 1430422-30-2
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

Guidance literature:: 6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘(1‘H)one; With tetraphosphorus decasulfide; In pyridine; at 120 ℃; for 1h;

With tert.-butylhydroperoxide; ammonia; at 20 ℃; for 16h;

Reference yield:

: 1430422-24-4
N-(6-bromo-3,3-dimethyl-4-vinylchroman-4-yl)-2-methylpropane-2-sulfinamide

: 1430422-30-2
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 0.5 h / 0 - 20 °C / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.1 h

2.2: 16 h

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 0.67 h / 120 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 80 °C

5.1: tetraphosphorus decasulfide / pyridine / 1 h / 120 °C

5.2: 16 h / 20 °C

With hydrogenchloride; Hoveyda-Grubbs catalyst second generation; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetraphosphorus decasulfide; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; pyridine; 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol; 4.1: |Suzuki Coupling / 5.1: |Suzuki Coupling;

Reference yield:

: 1430422-25-5
6-bromo-3,3-dimethyl-4-vinylchroman-4-amine

: 1430422-30-2
6-(3,5-difluorophenyl)-4‘-fluoro-3,3-dimethyl spiro[chroman-4,2‘-pyrrol]-5‘-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.1 h

1.2: 16 h

2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 0.67 h / 120 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 80 °C

4.1: tetraphosphorus decasulfide / pyridine / 1 h / 120 °C

4.2: 16 h / 20 °C

With Hoveyda-Grubbs catalyst second generation; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetraphosphorus decasulfide; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In pyridine; 1,2-dimethoxyethane; dichloromethane; water; 3.1: |Suzuki Coupling / 4.1: |Suzuki Coupling;