4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

Base Information

Chemical Name:4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile
CAS No.:1402892-04-9
Molecular Formula:C₂₂H₁₆ClFN₄
Molecular Weight:390.847
Hs Code.:

Synonyms:4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

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Chemical Property of 4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

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Technology Process of 4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

There total 5 articles about 4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402892-36-7
4-(4-chloro-2-fluorophenyl)-4-(7-iodo-1H-indazole-3-yl)butanenitrile

: 1692-25-7
3-pyridylboronic acid

: 1402892-04-9
4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 3h;

Reference yield:

: 194240-75-0
2-(4-chloro-2-fluorophenyl)acetic acid

: 1402892-04-9
4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 °C

1.2: 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: hydrazine / pyridine / 0.5 h / 120 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

With sodium hexamethyldisilazane; sodium hydrogencarbonate; lithium hexamethyldisilazane; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; water; 1.1: Claisen Reaction / 4.1: Suzuki Coupling;

Reference yield:

: 1260830-14-5
methyl 2-fluoro-3-iodobenzoate

: 1402892-04-9
4-(4-chloro-2-fluorophenyl)-4-(7-pyridin-3-yl-1H-indazol-3-yl)butanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 °C

1.2: 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: hydrazine / pyridine / 0.5 h / 120 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

With sodium hexamethyldisilazane; sodium hydrogencarbonate; lithium hexamethyldisilazane; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; water; 1.1: Claisen Reaction / 4.1: Suzuki Coupling;