4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

Base Information

Chemical Name:4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile
CAS No.:1402892-35-6
Molecular Formula:C₁₇H₁₁ClF₂INO
Molecular Weight:445.635
Hs Code.:

Synonyms:4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

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Chemical Property of 4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

Chemical Property:

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Technology Process of 4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

There total 3 articles about 4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402892-33-4
2-(4-chloro-2-fluorophenyl)-1-(2-fluoro-3-iodophenyl)ethanone

: 107-13-1,25014-41-9
acrylonitrile

: 1402892-35-6
4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

Guidance literature:: 2-(4-chloro-2-fluorophenyl)-1-(2-fluoro-3-iodophenyl)ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

acrylonitrile; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 194240-75-0
2-(4-chloro-2-fluorophenyl)acetic acid

: 1402892-35-6
4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 °C

1.2: 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

With sodium hexamethyldisilazane; lithium hexamethyldisilazane; In tetrahydrofuran; 1.1: Claisen Reaction;

Reference yield:

: 1260830-14-5
methyl 2-fluoro-3-iodobenzoate

: 1402892-35-6
4-(4-chloro-2-fluorophenyl)-5-(2-fluoro-3-iodophenyl)-5-oxopentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 °C

1.2: 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

With sodium hexamethyldisilazane; lithium hexamethyldisilazane; In tetrahydrofuran; 1.1: Claisen Reaction;