2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

Base Information

Chemical Name:2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole
CAS No.:1426259-87-1
Molecular Formula:C₂₄H₂₄N₄O
Molecular Weight:384.481
Hs Code.:

Synonyms:2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

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Chemical Property of 2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

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Technology Process of 2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

There total 4 articles about 2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 53014-84-9
2-methyl-5-formylpyridine

: 885275-02-5
2-(4-(piperazin-1-yl)phenyl)benzo[d]oxazole

: 1426259-87-1
2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

Guidance literature:: With formic acid; In N,N-dimethyl-formamide; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml300472n

Reference yield:

: 197638-83-8
4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzaldehyde

: 1426259-87-1
2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen / toluene / 12 h / 120 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: formic acid / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

With formic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml300472n

Reference yield:

: 1428536-33-7
tert-butyl 4-(4-(benzo[d]oxazol-2-yl)phenyl)piperazine-1-carboxylate

: 1426259-87-1
2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: formic acid / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

With formic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml300472n