2-(4-PIPERAZIN-1-YL-PHENYL)-BENZOOXAZOLE

Base Information

• Chemical Name: 2-(4-PIPERAZIN-1-YL-PHENYL)-BENZOOXAZOLE
• CAS No.: 885275-02-5
• Molecular Formula: C17H17 N3 O
• Molecular Weight: 279.34
• Hs Code.: 2934999090
• Mol file: 885275-02-5.mol

Synonyms:2-(4-PIPERAZIN-1-YL-PHENYL)-BENZOOXAZOLE

Chemical Property of 2-(4-PIPERAZIN-1-YL-PHENYL)-BENZOOXAZOLE

Chemical Property:

• PSA: 41.30000
• LogP: 3.29820

Purity/Quality:

98% ^*data from raw suppliers

2-(4-Piperazin-1-yl-phenyl)-benzooxazole 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-PIPERAZIN-1-YL-PHENYL)-BENZOOXAZOLE

There total 3 articles about 2-(4-PIPERAZIN-1-YL-PHENYL)-BENZOOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-butyl 4-(4-(benzo[d]oxazol-2-yl)phenyl)piperazine-1-carboxylate (1428536-33-7) → 2-(4-(piperazin-1-yl)phenyl)benzo[d]oxazole (885275-02-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ml300472n

Reference yield:

2-amino-phenol (95-55-6) → 2-(4-(piperazin-1-yl)phenyl)benzo[d]oxazole (885275-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen / toluene / 12 h / 120 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1021/ml300472n

Reference yield:

4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzaldehyde (197638-83-8) → 2-(4-(piperazin-1-yl)phenyl)benzo[d]oxazole (885275-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen / toluene / 12 h / 120 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1021/ml300472n

upstream raw materials:

2-amino-phenol

4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzaldehyde

tert-butyl 4-(4-(benzo[d]oxazol-2-yl)phenyl)piperazine-1-carboxylate

Downstream raw materials:

2-(4-(4-(pyridin-3-ylmethyl)piperazin-1-yl)phenyl)benzo[d]oxazole

2-(4-(4-(thiophen-2-ylmethyl)piperazin-1-yl)phenyl)benzo[d]oxazole

2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

2-(4-(4-((6-fluoropyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

Refernces