(R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

Base Information

Chemical Name:(R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide
CAS No.:1437034-25-7
Molecular Formula:C₁₉H₁₅ClFN₃O₄
Molecular Weight:403.797
Hs Code.:

Synonyms:(R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

Chemical Property:

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Technology Process of (R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

There total 6 articles about (R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437034-77-9
C₁₉H₁₃ClFN₃O₂

: 1437034-25-7
(R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

Guidance literature:: With AD-mix β; water; In isopropyl alcohol; at 0 - 20 ℃; for 48h;

Reference yield:

: 1437034-72-4
2-(4-(5-chloro-2-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,3-dioxaborolane

: 1437034-25-7
(R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water; 1,2-dimethoxyethane / 4 h / 95 °C / Sealed tube

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ammonium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3: AD-mix β; water / isopropyl alcohol / 48 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; AD-mix β; water; ammonium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1437034-25-7
(R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C

2: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water; 1,2-dimethoxyethane / 4 h / 95 °C / Sealed tube

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ammonium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: AD-mix β; water / isopropyl alcohol / 48 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; AD-mix β; water; ammonium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;