N³,N⁴-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide

Base Information

• Chemical Name: N³,N⁴-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide
• CAS No.: 1608108-08-2
• Molecular Formula: C₂₃H₂₃N₇O₄S₂
• Molecular Weight: 525.612

Synonyms:N³,N⁴-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide

Chemical Property of N³,N⁴-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide

Chemical Property:

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Technology Process of N³,N⁴-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide

There total 3 articles about N³,N⁴-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethyl-2-thiourea (625-53-6) + 1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarbonyl dichloride (1608107-87-4) → N3,N4-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide (1608108-08-2)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 6h;

DOI:10.1016/j.ejmech.2014.03.033

Reference yield:

1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid (96723-10-3) → N3,N4-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide (1608108-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / 80 °C

2: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / 140 °C

With thionyl chloride; In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.ejmech.2014.03.033

Reference yield:

4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (1152334-07-0) → N3,N4-bis(ethylcarbamothioyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxamide (1608108-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water / 3 h / 100 °C

2: thionyl chloride / 5 h / 80 °C

3: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / 140 °C

With thionyl chloride; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water;

DOI:10.1016/j.ejmech.2014.03.033

upstream raw materials:

1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid

ethyl-2-thiourea

1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarbonyl dichloride

4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

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