2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

Base Information

Chemical Name:2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide
CAS No.:189632-43-7
Molecular Formula:C₂₀H₃₁BrN₂O₄
Molecular Weight:443.381
Hs Code.:

Synonyms:2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

Chemical Property:

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Technology Process of 2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

There total 3 articles about 2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 112245-13-3
(S)-tert-leucinol

: 151603-30-4
2-bromobenzene-1,3-dicarboxylic acid dichloride

: 189632-43-7
2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

Guidance literature:: With triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1021/jo9702397

Reference yield:

: 22433-91-6
2-bromoisophthalic acid

: 189632-43-7
2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / SOCl₂ / 1 h / Heating

2: 74 percent / Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jo9702397

Reference yield:

: 576-22-7
2-Bromo-m-xylene

: 189632-43-7
2-Bromo-N,N'-bis-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-isophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium permanganate; water / tert-butyl alcohol

2: thionyl chloride / tert-butyl alcohol

3: triethylamine / dichloromethane

With potassium permanganate; thionyl chloride; water; triethylamine; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/om500144b