C₂₅H₂₆F₃N₃O₃

Base Information

• Chemical Name: C₂₅H₂₆F₃N₃O₃
• CAS No.: 1421348-41-5
• Molecular Formula: C₂₅H₂₆F₃N₃O₃
• Molecular Weight: 473.495
• Mol file: 1421348-41-5.mol

Synonyms:C₂₅H₂₆F₃N₃O₃

Chemical Property of C₂₅H₂₆F₃N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₆F₃N₃O₃

There total 10 articles about C₂₅H₂₆F₃N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.6%

(+/-)-3-[4-(1-amino-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester (1421348-70-0) + 2-chloro-7-(trifluoromethyl)quinoline (83183-56-6) → C25H26F3N3O3 (1421348-41-5)

Guidance literature:

With dicyclohexyl[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine; palladium diacetate; sodium t-butanolate; In tetrahydrofuran; at 90 ℃; Inert atmosphere; Sealed tube;

Reference yield:

(+/-)-4-(1-hydroxy-3-methyl-butyl)-benzoic acid ethyl ester (1393125-62-6) → C25H26F3N3O3 (1421348-41-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / tetrahydrofuran / 20 - 60 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

4: hydrazine hydrate / ethanol / Reflux

5: palladium diacetate; dicyclohexyl[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine; sodium t-butanolate / tetrahydrofuran / 90 °C / Inert atmosphere; Sealed tube

With dicyclohexyl[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine; di-isopropyl azodicarboxylate; palladium diacetate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

4-iodobenzoic acid ethyl ester (51934-41-9) → C25H26F3N3O3 (1421348-41-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: TurboGrignard / tetrahydrofuran / 0.67 h / -40 - -30 °C

1.2: -35 - 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 20 - 60 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

5.1: hydrazine hydrate / ethanol / Reflux

6.1: palladium diacetate; dicyclohexyl[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine; sodium t-butanolate / tetrahydrofuran / 90 °C / Inert atmosphere; Sealed tube

With TurboGrignard; dicyclohexyl[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine; di-isopropyl azodicarboxylate; palladium diacetate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

(+/-)-4-(1-hydroxy-3-methyl-butyl)-benzoic acid ethyl ester

4-iodobenzoic acid ethyl ester

(+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester

isovaleraldehyde