(+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester

Base Information

• Chemical Name: (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester
• CAS No.: 1421348-68-6
• Molecular Formula: C₁₉H₂₉NO₄
• Molecular Weight: 335.444
• Mol file: 1421348-68-6.mol

Synonyms:(+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester

Chemical Property of (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester

There total 4 articles about (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 3-aminopropanoate (15231-41-1) + (+/-)-4-(1-hydroxy-3-methyl-butyl)-benzoic acid → (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester (1421348-68-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

Reference yield:

(+/-)-4-(1-hydroxy-3-methyl-butyl)-benzoic acid ethyl ester (1393125-62-6) → (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester (1421348-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 20 - 60 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

4-iodobenzoic acid ethyl ester (51934-41-9) → (+/-)-3-[4-(1-hydroxy-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester (1421348-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TurboGrignard / tetrahydrofuran / 0.67 h / -40 - -30 °C

1.2: -35 - 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 20 - 60 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

With TurboGrignard; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

(+/-)-4-(1-hydroxy-3-methyl-butyl)-benzoic acid ethyl ester

4-iodobenzoic acid ethyl ester

tert-butyl 3-aminopropanoate

isovaleraldehyde

Downstream raw materials:

(+/-)-3-[4-(1-amino-3-methyl-butyl)-benzoylamino]-propionic acid tert-butyl ester

C₂₄H₂₇N₃O₃

C₂₃H₂₅FN₄O₃

C₂₅H₂₆F₃N₃O₃