N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

Base Information

Chemical Name:N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine
CAS No.:172161-51-2
Molecular Formula:C₂₃H₃₁N₅O₃SSi
Molecular Weight:485.682
Hs Code.:

N<sup>6</sup>-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

Synonyms:N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

Suppliers and Price of N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

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Technology Process of N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

There total 4 articles about N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 172161-66-9
5'-S-acetyl-N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

: 172161-51-2
N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/00404-0399(50)1393-V

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 172161-51-2
N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / imidazole / dimethylformamide / 20 h / 20 °C

2: 52 percent / NaOH; MeOH / 1 h / 0 °C

With 1H-imidazole; methanol; sodium hydroxide; In N,N-dimethyl-formamide; 1: silylation / 2: methanolysis;
DOI:10.1139/cjc-77-8-1410

Reference yield:

: 4546-72-9
N₆-benzoyl-2'-deoxyadenosine

: 172161-51-2
N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thioadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C

2: 91 percent / imidazole / dimethylformamide / 20 h / 20 °C

3: 52 percent / NaOH; MeOH / 1 h / 0 °C

With 1H-imidazole; methanol; sodium hydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Mitsunobu coupling / 2: silylation / 3: methanolysis;
DOI:10.1139/cjc-77-8-1410