(2-bromo-5-chlorophenyl)hydrazine

Base Information

• Chemical Name: (2-bromo-5-chlorophenyl)hydrazine
• CAS No.: 922552-53-2
• Molecular Formula: C₆H₆BrClN₂
• Molecular Weight: 221.484
• Mol file: 922552-53-2.mol

Synonyms:(2-bromo-5-chlorophenyl)hydrazine

Chemical Property of (2-bromo-5-chlorophenyl)hydrazine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(2-Bromo-5-chlorophenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (2-Bromo-5-chlorophenyl)hydrazine can be used as reactant/reagent in synthetic preparation of tryptamine derivatives and use of bromine atom as a protecting group. It can also be used for preparation of amides of amino acids and analogs as antiviral agents.

Technology Process of (2-bromo-5-chlorophenyl)hydrazine

There total 2 articles about (2-bromo-5-chlorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromo-4-chloro-2-fluorobenzene (1996-29-8) → (2-bromo-5-chlorophenyl)hydrazine (922552-53-2)

Guidance literature:

With hydrazine hydrate; In dimethyl sulfoxide; at 70 ℃; for 72h;

DOI:10.1016/j.tetlet.2013.12.025

Reference yield:

→ (2-bromo-5-chlorophenyl)hydrazine (922552-53-2)

Guidance literature:

Reference yield: 95.8%

(2-bromo-5-chlorophenyl)hydrazine (922552-53-2) + bis(3-methoxyphenyl)disulfide (59014-89-0) → 2-chloro-7-methoxy-10H-phenothiazine (1730-44-5)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; 1-(2-hydroxyethyl)-2,3-dimethylimidazolium hexafluorophosphate; 1,1'-bis(diisopropylphosphino)ferrocene; tetracarbonyl nickel; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; chlorobenzene; at 70 ℃; for 10h; Reagent/catalyst; Solvent;

upstream raw materials:

1-bromo-4-chloro-2-fluorobenzene

Downstream raw materials:

2,8-dichloro-10H-phenothiazine

2-chloro-7-methoxy-10H-phenothiazine

1'-(tert-butyloxycarbonyl)-4-chlorospiro[indoline-3,4'-piperidine]-2-one

Refernces

• 1、 -. "1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS". Page/Page column 57. . Retrieved 2009/07/03.