1996-29-8 Usage
Description
1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene derivative characterized by its clear colorless to pale yellow liquid appearance. It is known for its chemical reactivity, particularly in Suzuki coupling reactions with 2-cyanoarylboronic esters to form biphenyls, which are precursors for synthesizing 6-substituted phenanthridines. 1-Bromo-4-chloro-2-fluorobenzene also exhibits unique physical properties, such as an enthalpy of vaporization of 40.737 kJ/mol at its boiling point (467.15K).
Uses
Used in Pharmaceutical Industry:
1-Bromo-4-chloro-2-fluorobenzene is used as a starting material for the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor. This application is significant due to its role in the development of potential treatments for various diseases and conditions that involve the IKK2 pathway.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1-Bromo-4-chloro-2-fluorobenzene is utilized in the preparation of benzonorbornadiene derivatives. These derivatives are valuable intermediates in the synthesis of various complex organic compounds and have potential applications in material science and pharmaceuticals.
Used in Antimicrobial Applications:
1-Bromo-4-chloro-2-fluorobenzene is also recognized for its antibacterial and antifungal activities, making it a valuable compound in the development of new antimicrobial agents. This application is particularly important in the context of increasing antibiotic resistance and the need for novel, effective treatments against a wide range of microbial pathogens.
Check Digit Verification of cas no
The CAS Registry Mumber 1996-29-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,9 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1996-29:
(6*1)+(5*9)+(4*9)+(3*6)+(2*2)+(1*9)=118
118 % 10 = 8
So 1996-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrClF/c7-5-2-1-4(8)3-6(5)9/h1-3H
1996-29-8Relevant articles and documents
PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES
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Paragraph 00139; 00154, (2017/07/28)
The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.
1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS
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Page 58, (2008/06/13)
Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.