6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one

Base Information

• Chemical Name: 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one
• CAS No.: 1235479-02-3
• Molecular Formula: C₂₀H₁₅NOS
• Molecular Weight: 317.411
• Mol file: 1235479-02-3.mol

Synonyms:6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one

Chemical Property of 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one

There total 3 articles about 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N‐methyl‐2‐thiophenecarboxamide (39880-77-8) + diphenyl acetylene (501-65-5) → 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one (1235479-02-3)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In tert-Amyl alcohol; at 110 ℃; for 16h;

DOI:10.1021/ja103776u

Reference yield: 42.0%

N‐methyl‐2‐thiophenecarboxamide (39880-77-8) + diphenyl acetylene (501-65-5) → 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one (1235479-02-3) + 3-(1,2-diphenylvinyl)-N-methylthiophene-2-carboxamide (1315257-26-1) + 3-(1,2-diphenylvinyl)-N-methylthiophene-2-carboxamide (1315257-18-1)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate monohydrate; In tert-Amyl alcohol; at 100 ℃; for 22h; optical yield given as %de; Inert atmosphere;

DOI:10.1002/anie.201101943

Reference yield:

2-Thiophenecarbonyl chloride (5271-67-0) → 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one (1235479-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h

2: palladium diacetate; sodium iodide dihydrate; potassium carbonate; copper diacetate / N,N-dimethyl-formamide / 36 h / 120 °C

With sodium iodide dihydrate; copper diacetate; palladium diacetate; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c2ob26668g

upstream raw materials:

N‐methyl‐2‐thiophenecarboxamide

diphenyl acetylene

2-Thiophenecarbonyl chloride