39880-77-8

Basic information

• Product Name: 2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI)
• Synonyms: 2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI);Thiophene-2-carboxylic acid methylamide;TenoxicaM IMpurity C (N-Methylthiophene-2-carboxaMide)
• CAS NO: 39880-77-8
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• Product Categories: AMIDE
• Mol File: 39880-77-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 142-145℃ (decomposition)
• Boiling Point: 328.3°C at 760 mmHg
• Flash Point: 152.3°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0.000191mmHg at 25°C
• Refractive Index: 1.554
• PKA: 14.81±0.46(Predicted)
• CAS DataBase Reference: 2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI)(39880-77-8)
• EPA Substance Registry System: 2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI)(39880-77-8)

Safety Data

• Hazardous Substances Data: 39880-77-8(Hazardous Substances Data)

Usage

Uses

N-Methylthiophene-2-carboxamide is an impurity of Tenoxicam (T019500), a nonsteroidal anti-inflamatory agent.

InChI:InChI=1/C6H7NOS/c1-7-6(8)5-3-2-4-9-5/h2-4H,1H3,(H,7,8)

Upstream product

• 1003-31-2 thiophene-2-carbonitrile 
• 67-56-1 methanol 

Downstream Products

• 1519051-17-2 N'-(2-fluorophenyl)-N-methylthiophene-2-carboximidamide 
• 2810-04-0 Ethyl thiophene-2-carboxylate 
• 10354-43-5 thiophene-2-carboxylic acid benzylamide 
• 930018-51-2 N-methyl-3-phenylthiophene-2-carboxamide 
• 1235479-02-3 6-methyl-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one 
• 1315257-26-1 3-(1,2-diphenylvinyl)-N-methylthiophene-2-carboxamide 
• 1315257-18-1 3-(1,2-diphenylvinyl)-N-methylthiophene-2-carboxamide 
• 156330-48-2 methyl N-(2,4,6-trimethyl)phenylthiophene-2-carboximidate 
• 156330-45-9 N-(2,4,6-trimethyl)phenylthiophene-2-carboximidoyl chloride 
• 70608-30-9 N-(2,4,6-trimethyl)phenylthiophene-2-carboxamide 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 527-72-0 2-thiophenylcarboxylic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 71267-32-8 N-methylthiophene-2-carboximidoyl chloride 

Relevant articles and documents

Atom-Economical and Tandem Conversion of Nitriles to N-Methylated Amides Using Methanol and Water

A cobalt complex catalyzed tandem conversion of nitrile to N-methylated amide is described using a methanol and water mixture. Using this protocol, several nitriles were directly and efficiently converted to the desired N-methylated amides. Kinetic experiments using H2O18 and CD3OD suggested that water and methanol were the source of the oxygen atom and methyl group, respectively, in the final N-methylated amides. Importantly, the participation of active Co(I)-H species in this transformation was realized from the control experiment. The kinetic isotope effect (KIE) study suggested that the activation of the C-H bond of methanol was a kinetically important step. The Hammett plot confirmed that the reaction was faster with the electron deficient nitriles. In addition, the plausible pathway for the formation of N-methylated amides from the nitriles was supported by the computational study.