(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

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Chemical Name:(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one
CAS No.:344315-33-9
Molecular Formula:C₄₀H₅₅IO₇S₂Si
Molecular Weight:866.994
Hs Code.:

(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

Synonyms:(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

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Chemical Property of (3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

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Technology Process of (3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

There total 34 articles about (3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109-80-8
1.3-propanedithiol

: 344315-42-0
(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-oxo-propyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

: 344315-33-9
(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

: 344315-32-8
[(2S,3S,4R,4aR,5aR,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-oxo-propyl)-7-triethylsilanyl-2,3,4,4a,5a,6,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-9-yl]-acetic acid

: 344315-33-9
(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: I(collidine)2PF₆ / CH₂Cl₂ / 2 h / 20 °C

2: 392 mg / Zn(OTf)2 / CH₂Cl₂ / 2 h / 20 °C

With zinc trifluoromethanesulfonate; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In dichloromethane;
DOI:10.1016/S0040-4020(02)00044-3

Reference yield:

: 344315-31-7
2-((2S,3S,4R,4aR,5aR,9R,10aS,11aR)-2-Allyl-3,4-bis-benzyloxy-7-triethylsilanyl-2,3,4,4a,5a,6,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-9-yl)-ethanol

: 344315-33-9
(3aR,4aS,5aR,7S,8S,9R,9aR,10aR,12S,12aS)-8,9-Bis-benzyloxy-12-iodo-7-(2-methyl-[1,3]dithian-2-ylmethyl)-12-triethylsilanyl-dodecahydro-1,4,6,10-tetraoxa-naphtho[2,3-f]azulen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / O₂; CuCl; PdCl₂ / dimethylformamide; H₂O / 48 h / 20 °C

2: Jones' reagent / acetone / 0.5 h / 0 °C

3: I(collidine)2PF₆ / CH₂Cl₂ / 2 h / 20 °C

4: 392 mg / Zn(OTf)2 / CH₂Cl₂ / 2 h / 20 °C

With jones' reagent; oxygen; zinc trifluoromethanesulfonate; copper(l) chloride; palladium dichloride; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; acetone; 1: Wacker oxidation;
DOI:10.1016/S0040-4020(02)00044-3