109-80-8 Usage
Application
Used as a usual flavor.
Toxicity
GRAS(FEMA)
Usage restriction
FEMA：baked goods, meat product, soups, snack foods, sauces, candy and sugar cream: 0.2mg/kg.
Chemical Properties
Different sources of media describe the Chemical Properties of 109-80-8 differently. You can refer to the following data:
1. 1,3-Propanedithiol has a sulfur, meaty odor. FEMA indicates that total dithiol added to any food should not exceed 1.0 ppm.
2. colourless to slightly yellow liquid
Occurrence
Reported found in cooked or boiled beef.
Uses
1,3-Propanedithiol is used as a reagent in the preparation of thioketals and thioacetals. It acts as a flavoring agent. It is used as a precursor in the synthesis of cyclic dithioacetal (1,3-dithiane) derivatives of carbonyl compounds. It is involved in the preparation of diiron propanedithiolate hexacarbonyl by reacting reaction with triiron dodecacarbonyl. Further, it is used for the protection of aldehydes and ketones through their reversible formation of dithianes. In addition to this, it reacts with metal ions to form chelate rings.
Definition
ChEBI: A dithiol that is propane substituted by thiol groups at positions 1 ans 3.
General Description
Clear orange oil with a disagreeable odor.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Organosulfides, such as 1,3-Dimercaptopropane, are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. 1,3-Dimercaptopropane may react with oxidizers, bases, reducing agents and alkali metals.
Fire Hazard
1,3-Dimercaptopropane is combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 109-80-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 109-80:
(5*1)+(4*0)+(3*9)+(2*8)+(1*0)=48
48 % 10 = 8
So 109-80-8 is a valid CAS Registry Number.
InChI:InChI=1/C3H8S2/c4-2-1-3-5/h4-5H,1-3H2
109-80-8Relevant articles and documents
Synthesis of thietane from sulfur and 1-bromo-3-chloropropane in hydrazine hydrate-alkali system
Russavskaya,Levanova,Klyba,Zhanchipova,Grabel'nykh,Sukhomazova,Albanov,Kochervin,Deryagina
, p. 156 - 157 (2006)
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Photosensitized cleavage of the dithio protecting group by visible light
Epling, Gary A.,Wang, Qingxi
, p. 5909 - 5912 (1992)
Dithio derivatives of aldehydes and ketones have been deprotected under neutral conditions using visible light provided by a 120 Watt spotlight and methylene green as a sensitizer. The key step in the deprotection is apparently an electron transfer from the dithio derivative to the electronically excited visible dye. The resulting dithio radical cation undergoes fragmentation, and the corresponding aldehydes and ketones are isolated in excellent yields.
Reduction of thiocols to alkanepolythiols with benzeneselenol
Shilkina,Papernaya,Deryagina
, p. 263 - 265 (2007/10/03)
Heating of benzeneselenol with polymethylene disulfides to 40-120°C results in formation of the corresponding alkanedithiols or alkanetrithiols and diphenyl diselenide. Poly(tetramethylene disulfide) reacts with benzeneselenol to give 1,2-dithiane and diphenyl diselenide. A radical mechanism of this reaction is discussed.
Synthesis of thiols via palladium catalyzed methanolysis of thioacetates with borohydride exchange resin
Choi,Yoon
, p. 2655 - 2663 (2007/10/02)
Various thiols are prepared quantitatively from the corresponding thioacetates via Pd catalyzed methanolysis with borohydride exchange resin under a mild and neutral conditions. One-pot synthesis of thiols from alkyl halides through the formation of alkyl thioacetates using thioacetate exchange resin followed by methanolysis is also described.
