3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

Base Information

Chemical Name:3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide
CAS No.:1418274-12-0
Molecular Formula:C₂₉H₂₅Cl₃N₂O₅S
Molecular Weight:619.953
Hs Code.:

Synonyms:3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

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Chemical Property of 3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

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Technology Process of 3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

There total 10 articles about 3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1418274-12-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

Guidance literature:: With ammonium hydroxide; In acetonitrile;

Reference yield:

: 1418274-38-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzene-1-sulfonyl chloride

: 1418274-12-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

Guidance literature:: With ammonium hydroxide; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 946426-89-7
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

: 1418274-12-0
3-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 21 h / 20 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: -78 - 20 °C

3.1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / 115 °C / Inert atmosphere

4.1: acetic acid; 1,3-dichloro-5,5-dimethylhydantoin / water; acetonitrile / 2 h / 0 - 5 °C

5.1: ammonium hydroxide / acetonitrile / 1 h / 20 °C

With ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; 1,3-dichloro-5,5-dimethylhydantoin; di-isopropyl azodicarboxylate; potassium carbonate; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; hexane; water; toluene; acetonitrile;